On behalf of the Global Health Institute at SUNY Upstate Medical University we are delighted to welcome you to the 2026 Dengue Endgame Summit. Recent advances in dengue vaccines, antivirals, therapeutics, biologics, and vector control have renewed hope that dengue control may be an achievable goal. However, these technological and medical advances are emerging into a world challenged by climate change, increasing urbanization, expanded regional and international travel, and viral evolution. Our collective optimism is currently being tempered by the harsh reality of dengue on the ground, where we are witnessing record breaking dengue outbreaks around the world and increasing morbidity and mortality. However, we strongly believe there is reason for hope and an opportunity for the scientific, medical, and public health communities to unite and advance towards a future where dengue and other vector-borne diseases are concerns of the past.