The 2026 2nd International Symposium on Bioinformatics and Computational Biology (ISBCB 2026) will be held from April 17 to 19, 2026 in Zhengzhou, China. Bioinformatics and Computational Biology, as indispensable components of modern life sciences, have propelled advancements and breakthroughs in the field of biology by integrating knowledge from computer science, mathematics, and statistics. In this information age, the application of bioinformatics has profoundly transformed our understanding of genomics, transcriptomics, proteomics, and other domains, providing powerful tools for personalized medicine, drug design, ecological research