The IEEE International Conference on Automation Science and Engineering (CASE) is the flagship automation conference of the IEEE Robotics and Automation Society (RAS) and constitutes the primary forum for cross-industry and multidisciplinary research in automation. Its goal is to provide broad coverage and dissemination of foundational research in automation among researchers and practitioners. CASE 2025 will be held on August 17 – August 21, 2025, in Los Angeles, California, USA. The pre-conference workshops will be held on August 17, 2025.